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In modern culture the spiritual use of cannabis has been spread by the disciples of the Rastafari movement who use cannabis as a sacrament and as an aid to meditation.The earliest known reports regarding the sacred status of cannabis in India and Nepal come from the Atharva Veda estimated to have been written sometime around 2000–1400 BCE.
sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use.
According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011.
These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use.
Heavy, long term exposure to marijuana may have biologically-based physical, mental, behavioral and social health consequences and may be "associated with diseases of the liver (particularly with co-existing hepatitis C), lungs, heart, and vasculature".
Acute effects may include anxiety and panic, impaired attention, and memory (while intoxicated), an increased risk of psychotic symptoms, and possibly an increased risk of accidents if a person drives a motor vehicle while intoxicated.
Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation.
Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made.The drug use must be "implicated" in the emergency department visit, but does not need to be the direct cause of the visit.Most of the illicit drug emergency room visits involved multiple drugs.A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users.It was also shown that giving THC or cannabis correlated with increased bloodflow in these areas, and facilitated activation of the anterior cingulate cortex and frontal cortex when participants were presented with assignments demanding use of cognitive capacity.There are several references in Greek mythology to a powerful drug that eliminated anguish and sorrow.