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Children with autism have been shown to have increased oxidative stress and less reduced (active) glutathione HBOT, especially when using pressures less than 2.0 atmospheres, can up-regulate these antioxidant enzymes and afford antioxidant protection against oxidative stress.Mitochondria are the energy producing organelles of the body.

Because porphyrin is involved in the production of functional heme/hemoglobin, and because this appears to be disordered in autism, the impaired delivery of oxygen to cells will be improved when HBOT bypasses hemoglobin-dependent oxygenation.You will hear many terms used interchangeably by lay people and professionals alike: hyperbaric oxygen therapy (HBOT), mild hyperbaric oxygen therapy (m HBOT), hyperbaric therapy (HBT), hyperbaric oxygen (HBO), hyperbaric air therapy (HBAT), hyperbaric enriched air therapy (HBEAT), etc. There is also no doubt that it works well at low pressures with varying degrees of oxygen concentrations as well as at varying degrees of high pressures with 100% oxygen.However, the most common way the term is used by the autism community is to just say "HBOT". Kartzinel, and the tremendous number of children that have been treated by physicians such as Dr. The reason I recommend HBOT for all my patients is because there is scientific evidence that pressure, independent of the concentration of oxygen, decreases inflammation and that any concentration of oxygen under any increased amount of pressure will allow more oxygen to dissolve into the extracellular fluids of the body: plasma, lymph, cerebrospinal fluid, and interstitial fluid.Efrain Olszewer has pre- and post-angiograms documenting collateral circulation beginning as early as ten to twenty hours after initiating hyperbaric therapy for cerebral vascular disease and peripheral arteriosclerosis at pressures lower than 1.3 ATA It is known that one of the problems children with autism have is decreased blood flow to the brain (cerebral hypoperfusion).Therefore is has been speculated that angioneogenesis is the way that HBOT helps autism However, though angioneogenesis may be one mechanism by which children with autism are helped by HBOT, angioneogenesis may not be the primary mechanism by which HBOT works The amount of cerebral hypoperfusion in autistics compared to controls is about 8%, so a small increase in oxygen delivery may be all that is needed to overcome this deficit and show clinical benefit.C-reactive protein and high levels of cytokines have been shown to decrease with HBOT.

One study demonstrates that the anti-inflammatory effect from HBOT is probably due to pressure effects and not necessarily increased oxygen tension.

, not only due to the competing mechanisms of vasodilation and vasoconstriction, but also due to decreasing the inflammation that secondarily constricts blood vessel lumens in a closed spac.

Because inflammation is accompanied by swelling, tissue expansion or compression will occur.

SPECT scans demonstrate the relative amount of blood that is able to reach the different areas in the brain.

Color coding allows easy visualization of what is occurring with blue areas representing little blood flow and yellow areas indicating normal blood flow.

Therefore, whenever inflammation brings more fluid to a region of the body that is comprised of solid tissue and hollow blood vessels, the first thing to happen is that the hollow blood vessel lumens will be compressed and deliver fewer red cells carrying oxygen to the area.